Genomic landscape of liver cancer

A new exome sequencing study of individuals with hepatocellular carcinoma (HCC) reveals imprints of mutagenic exposure and identifies new genes contributing to tumorigenesis. This work joins several recent publications reporting whole-genome, exome and RNA sequencing in HCC, which together provide a comprehensive genomic landscape and new insights into the etiology of liver cancer.

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Figure 1: Imprints of mutagenic exposures in HCC.

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Correspondence to Zemin Zhang.

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The author declares no competing financial interests.

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Zhang, Z. Genomic landscape of liver cancer. Nat Genet 44, 1075–1077 (2012). https://xs.scihub.ltd/https://doi.org/10.1038/ng.2412

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