Browse Articles

  • Article
    | Open Access

    Adding minute amounts of rhenium to Ni-based single crystal superalloys extends their high temperature performance in engines, but the reasons behind that are still unclear. Here, the authors combine high resolution imaging and modelling to show that rhenium enriches and slows down partial dislocations to improve creep performance.

    • Xiaoxiang Wu
    • , Surendra Kumar Makineni
    • , Christian H. Liebscher
    • , Gerhard Dehm
    • , Jaber Rezaei Mianroodi
    • , Pratheek Shanthraj
    • , Bob Svendsen
    • , David Bürger
    • , Gunther Eggeler
    • , Dierk Raabe
    •  & Baptiste Gault
  • Article
    | Open Access

    Decoupled high-order MQW superlattices are desired to design miniaturized photonic sources but they are yet to be realized in scalable ways. Here Jagielski et al. achieve this goal using multiple-stacked colloidal lead halide perovskite quantum wells separated by atomically thin quantum barriers.

    • Jakub Jagielski
    • , Simon F. Solari
    • , Lucie Jordan
    • , Declan Scullion
    • , Balthasar Blülle
    • , Yen-Ting Li
    • , Frank Krumeich
    • , Yu-Cheng Chiu
    • , Beat Ruhstaller
    • , Elton J. G. Santos
    •  & Chih-Jen Shih
  • Article
    | Open Access

    Diffuse optical flowmetry is widely used to assess blood flow dynamics, but has remained difficult to interpret. Here, the authors use interferometric near-infrared spectroscopy, revealing additional information about optical phase and time-of-flight, and observe the Brownian nature of blood flow dynamics in humans.

    • Oybek Kholiqov
    • , Wenjun Zhou
    • , Tingwei Zhang
    • , V. N. Du Le
    •  & Vivek J. Srinivasan
  • Article
    | Open Access

    There are significant uncertainties of how large sea level changes due to Antarctic Ice Sheet melting could be. Here, the authors quantify the impact of different greenhouse gas emission scenarios and different Antarctic contributions to changes to extreme sea-level events and find that even under low emissions the occurrence of sea-level extremes could rise significantly due to Antarctic meltwater increase.

    • Thomas Frederikse
    • , Maya K. Buchanan
    • , Erwin Lambert
    • , Robert E. Kopp
    • , Michael Oppenheimer
    • , D. J. Rasmussen
    •  & Roderik S. W. van de Wal
  • Article
    | Open Access

    In contrast to the well-established palladium-catalyzed version, the nickel-catalyzed carbonylative coupling is underdeveloped. Here the authors report a nickel-catalyzed allylic carbonylative coupling with alkyl zinc reagents, allowing for preparation of β,γ-unsaturated ketones in a linear-selective fashion.

    • Yangyang Weng
    • , Chenhuan Zhang
    • , Zaiquan Tang
    • , Mohini Shrestha
    • , Wenyi Huang
    • , Jingping Qu
    •  & Yifeng Chen
  • Article
    | Open Access

    Neurogenesis is an ordered transition from pluriptotent cells to neural precursor cells (NPCs) to neurons. Here the authors show that loss of the lysine demethylases JMJD3 and UTX leads reduced DNA accessibility at neurogenesis loci in human NPCs, and that the chromatin remodeller BAF can rescue differentiation defects.

    • Yongli Shan
    • , Yanqi Zhang
    • , Yuan Zhao
    • , Tianyu Wang
    • , Jingyuan Zhang
    • , Jiao Yao
    • , Ning Ma
    • , Zechuan Liang
    • , Wenhao Huang
    • , Ke Huang
    • , Tian Zhang
    • , Zhenghui Su
    • , Qianyu Chen
    • , Yanling Zhu
    • , Chuman Wu
    • , Tiancheng Zhou
    • , Wei Sun
    • , Yanxing Wei
    • , Cong Zhang
    • , Chenxu Li
    • , Shuquan Su
    • , Baojian Liao
    • , Mei Zhong
    • , Xiaofen Zhong
    • , Jinfu Nie
    • , Duanqing Pei
    •  & Guangjin Pan
  • Article
    | Open Access

    Mutational signatures induced by ionising radiation remain largely unexplored. Here in TP53 mutant mice, the authors characterise the genomic landscape of tumours induced by high- and low-energy radiation.

    • Yun Rose Li
    • , Kyle D. Halliwill
    • , Cassandra J. Adams
    • , Vivek Iyer
    • , Laura Riva
    • , Rashid Mamunur
    • , Kuang-Yu Jen
    • , Reyno del Rosario
    • , Erik Fredlund
    • , Gillian Hirst
    • , Ludmil B. Alexandrov
    • , David Adams
    •  & Allan Balmain
  • Article
    | Open Access

    Beliefs that justify the economic system buffer against the aversive emotional impact of inequality. Here the authors show that system-justifying economic ideology predicts dampened negativity, measured using self-reported and physiological responses, to manifestations of poverty and wealth.

    • Shahrzad Goudarzi
    • , Ruthie Pliskin
    • , John T. Jost
    •  & Eric D. Knowles
  • Article
    | Open Access

    SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neuroendocrine differentiation of prostate cancer cells.

    • Ritika Tiwari
    • , Nishat Manzar
    • , Vipul Bhatia
    • , Anjali Yadav
    • , Mushtaq A. Nengroo
    • , Dipak Datta
    • , Shannon Carskadon
    • , Nilesh Gupta
    • , Michael Sigouros
    • , Francesca Khani
    • , Matti Poutanen
    • , Amina Zoubeidi
    • , Himisha Beltran
    • , Nallasivam Palanisamy
    •  & Bushra Ateeq
  • Article
    | Open Access

    Bacterial microcompartments (BMCs) consist of a protein shell and an encapsulated enzymatic core. Here, Kalnins et al. study a BMC from Klebsiella pneumoniae, show that the enzymatic core is encapsulated in a hierarchical manner, and solve the cryo-EM structure of a pT = 4 quasi-symmetric icosahedral shell particle.

    • Gints Kalnins
    • , Eva-Emilija Cesle
    • , Juris Jansons
    • , Janis Liepins
    • , Anatolij Filimonenko
    •  & Kaspars Tars
  • Article
    | Open Access

    The valve-like trichomes of the desert plant Tillandsia landbeckii allow water acquisition from fog while minimising transpiration. Here, Raux et al. show that a hygroscopic cell-wall adjacent to a semi-permeable plasma membrane at the base of the trichome confers this asymmetry in water conductance.

    • Pascal S. Raux
    • , Simon Gravelle
    •  & Jacques Dumais
  • Article
    | Open Access

    Precapillary sphincters are mural cells encircling an indentation of blood vessels where capillaries branch off from penetrating arterioles (PAs), but their existence and role in the brain is not fully understood. Here authors describe these structures at PAs in the cortex and show that they constrict during cortical spreading depolarization in mice.

    • Søren Grubb
    • , Changsi Cai
    • , Bjørn O. Hald
    • , Lila Khennouf
    • , Reena Prity Murmu
    • , Aske G. K. Jensen
    • , Jonas Fordsmann
    • , Stefan Zambach
    •  & Martin Lauritzen
  • Article
    | Open Access

    HER2-enriched breast cancers within the HER2-positive subtype are addicted to the HER2 pathway. Here, the authors analyse gene expression before, during, and after treatment with anti-HER2-based therapies in the phase II PAMELA clinical trial, finding phenotypic changes induced by treatment.

    • Fara Brasó-Maristany
    • , Gaia Griguolo
    • , Tomás Pascual
    • , Laia Paré
    • , Paolo Nuciforo
    • , Antonio Llombart-Cussac
    • , Begoña Bermejo
    • , Mafalda Oliveira
    • , Serafín Morales
    • , Noelia Martínez
    • , Maria Vidal
    • , Barbara Adamo
    • , Olga Martínez
    • , Sonia Pernas
    • , Rafael López
    • , Montserrat Muñoz
    • , Núria Chic
    • , Patricia Galván
    • , Isabel Garau
    • , Luis Manso
    • , Jesús Alarcón
    • , Eduardo Martínez
    • , Sara Gregorio
    • , Roger R. Gomis
    • , Patricia Villagrasa
    • , Javier Cortés
    • , Eva Ciruelos
    •  & Aleix Prat
  • Article
    | Open Access

    Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8.

    • Thorunn A. Olafsdottir
    • , Fannar Theodors
    • , Kristbjorg Bjarnadottir
    • , Unnur Steina Bjornsdottir
    • , Arna B. Agustsdottir
    • , Olafur A. Stefansson
    • , Erna V. Ivarsdottir
    • , Jon K. Sigurdsson
    • , Stefania Benonisdottir
    • , Gudmundur I. Eyjolfsson
    • , David Gislason
    • , Thorarinn Gislason
    • , Steinunn Guðmundsdóttir
    • , Arnaldur Gylfason
    • , Bjarni V. Halldorsson
    • , Gisli H. Halldorsson
    • , Thorhildur Juliusdottir
    • , Anna M. Kristinsdottir
    • , Dora Ludviksdottir
    • , Bjorn R. Ludviksson
    • , Gisli Masson
    • , Kristjan Norland
    • , Pall T. Onundarson
    • , Isleifur Olafsson
    • , Olof Sigurdardottir
    • , Lilja Stefansdottir
    • , Gardar Sveinbjornsson
    • , Vinicius Tragante
    • , Daniel F. Gudbjartsson
    • , Gudmar Thorleifsson
    • , Patrick Sulem
    • , Unnur Thorsteinsdottir
    • , Gudmundur L. Norddahl
    • , Ingileif Jonsdottir
    •  & Kari Stefansson
  • Article
    | Open Access

    As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual innate lymphoid cells (ILCs), identifying subsets with features distinct from blood ILC.

    • Oisín Huhn
    • , Martin A. Ivarsson
    • , Lucy Gardner
    • , Mike Hollinshead
    • , Jane C Stinchcombe
    • , Puran Chen
    • , Norman Shreeve
    • , Olympe Chazara
    • , Lydia E. Farrell
    • , Jakob Theorell
    • , Hormas Ghadially
    • , Peter Parham
    • , Gillian Griffiths
    • , Amir Horowitz
    • , Ashley Moffett
    • , Andrew M. Sharkey
    •  & Francesco Colucci
  • Article
    | Open Access

    The role of hydrogels in a wide range of applications stems from its stimuli-responsive properties, but coupling of separate stimuli in hydrogels is not often shown. Here the authors demonstrate the emergence of counterintuitive transient phenomena in a polyacrylic acid hydrogel caused by distinct responses to different combinations of rates and configurations of sequential stimuli.

    • Peter A. Korevaar
    • , C. Nadir Kaplan
    • , Alison Grinthal
    • , Reanne M. Rust
    •  & Joanna Aizenberg
  • Article
    | Open Access

    Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.

    • Silvia Giannini
    • , Melissa M. Lee-Sundlov
    • , Leonardo Rivadeneyra
    • , Christian A. Di Buduo
    • , Robert Burns
    • , Joseph T. Lau
    • , Hervé Falet
    • , Alessandra Balduini
    •  & Karin M. Hoffmeister
  • Article
    | Open Access

    Gene drives raise safety concerns around unintended propagation. Here the authors present a trans-complementing split-gene drive that requires inheritance of separate transgenes to assemble a fully functional drive.

    • Víctor López Del Amo
    • , Alena L. Bishop
    • , Héctor M. Sánchez C.
    • , Jared B. Bennett
    • , Xuechun Feng
    • , John M. Marshall
    • , Ethan Bier
    •  & Valentino M. Gantz
  • Article
    | Open Access

    Coupling photochemical derivatization with tandem mass spectrometry enables C=C-isomer resolved lipidomics. Here, the authors further develop this approach into a shotgun lipidomics workflow that allows simultaneous characterization of lipid C=C locations and sn-positions in complex biological samples.

    • Wenbo Cao
    • , Simin Cheng
    • , Jing Yang
    • , Jiaxin Feng
    • , Wenpeng Zhang
    • , Zishuai Li
    • , Qinhua Chen
    • , Yu Xia
    • , Zheng Ouyang
    •  & Xiaoxiao Ma
  • Article
    | Open Access

    Carbon nanomaterials have widespread application but fundamental aspects of their formation are still unclear. Here the authors explore the shock-induced synthesis of carbon nanoallotropes from liquid CO by time-resolved reflectivity and computations identifying the growth mechanism at the sub-nanosecond timescale

    • Michael R. Armstrong
    • , Rebecca K. Lindsey
    • , Nir Goldman
    • , Michael H. Nielsen
    • , Elissaios Stavrou
    • , Laurence E. Fried
    • , Joseph M. Zaug
    •  & Sorin Bastea
  • Article
    | Open Access

    The Mre11/Rad50 complex, which functions in genome surveillance, possesses antiparallel coiled-coil arms forming a ring-like structure similar to that of the SMC family proteins. Here the authors find that the Rad50 zinc hook functions similarly to the hinge of the SMC protein, and that the ring structure of the Mre11/Rad50 dimer also opens by disconnecting its globular head domains.

    • Hisashi Tatebe
    • , Chew Theng Lim
    • , Hiroki Konno
    • , Kazuhiro Shiozaki
    • , Akira Shinohara
    • , Takayuki Uchihashi
    •  & Asako Furukohri
  • Article
    | Open Access

    Antibodies expressed in the cytosol often form insoluble aggregates, which makes it hard to target intracellular proteins. Here the authors engineer an ultra-stable cytoplasmic antibody (STAND) with a low isoelectric point that can be used in vivo.

    • Hiroyuki Kabayama
    • , Makoto Takeuchi
    • , Naoko Tokushige
    • , Shin-ichi Muramatsu
    • , Miyuki Kabayama
    • , Mitsunori Fukuda
    • , Yoshiyuki Yamada
    •  & Katsuhiko Mikoshiba
  • Article
    | Open Access

    Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates Wnt ligands to promote gastrointestinal regeneration and development.

    • Ji-Eun Kim
    • , Lijiang Fei
    • , Wen-Chi Yin
    • , Sabrina Coquenlorge
    • , Abilasha Rao-Bhatia
    • , Xiaoyun Zhang
    • , Sammy Shun Wai Shi
    • , Ju Hee Lee
    • , Noah A. Hahn
    • , Wasi Rizvi
    • , Kyoung-Han Kim
    • , Hoon-Ki Sung
    • , Chi-chung Hui
    • , Guoji Guo
    •  & Tae-Hee Kim
  • Article
    | Open Access

    The HNF4α gene contains two promoters, which are thought to be active in the fetal and adult liver, the latter contributing to hepatic glucose production. Here the authors show that the fetal isoform of HNF4a is induced in mouse livers upon fasting and in type-2 diabetes in a manner regulated by TET3.

    • Da Li
    • , Tiefeng Cao
    • , Xiaoli Sun
    • , Sungho Jin
    • , Di Xie
    • , Xinmei Huang
    • , Xiaoyong Yang
    • , Gordon G. Carmichael
    • , Hugh S. Taylor
    • , Sabrina Diano
    •  & Yingqun Huang
  • Article
    | Open Access

    High throughput manufacturing of long length coated conductors requires fast epitaxial growth of high-temperature superconducting films. Here, Soler et al. report an ultrafast growth rates and high critical current densities of YBa2Cu3O7 films using a transient liquid-assisted growth method.

    • L. Soler
    • , J. Jareño
    • , J. Banchewski
    • , S. Rasi
    • , N. Chamorro
    • , R. Guzman
    • , R. Yáñez
    • , C. Mocuta
    • , S. Ricart
    • , J. Farjas
    • , P. Roura-Grabulosa
    • , X. Obradors
    •  & T. Puig
  • Article
    | Open Access

    High-performance transition metal catalysts are a major driving force in academic and industrial polyolefin research. Here the authors show the synthesis and (co)polymerization studies of a simple and versatile α-imino-ketone nickel system, which is thermally stable and highly active during ethylene polymerization.

    • Tao Liang
    • , Shabnam B. Goudari
    •  & Changle Chen
  • Article
    | Open Access

    Chronic lymphocytic leukemia is an indolent disease, and many patients succumb to infection rather than the direct effects of the disease. Here, the authors use medical records and machine learning to predict the patients that may be at risk of infection, which may enable a change in the course of their treatment.

    • Rudi Agius
    • , Christian Brieghel
    • , Michael A. Andersen
    • , Alexander T. Pearson
    • , Bruno Ledergerber
    • , Alessandro Cozzi-Lepri
    • , Yoram Louzoun
    • , Christen L. Andersen
    • , Jacob Bergstedt
    • , Jakob H. von Stemann
    • , Mette Jørgensen
    • , Man-Hung Eric Tang
    • , Magnus Fontes
    • , Jasmin Bahlo
    • , Carmen D. Herling
    • , Michael Hallek
    • , Jens Lundgren
    • , Cameron Ross MacPherson
    • , Jan Larsen
    •  & Carsten U. Niemann
  • Article
    | Open Access

    Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability.

    • Limin Zhao
    • , Hao Ke
    • , Haibo Xu
    • , Guo-Dong Wang
    • , Honglei Zhang
    • , Li Zou
    • , Shu Xiang
    • , Mengyuan Li
    • , Li Peng
    • , Mingfang Zhou
    • , Lingling Li
    • , Lei Ao
    • , Qin Yang
    • , Che-Kun James Shen
    • , Ping Yi
    • , Lu Wang
    •  & Baowei Jiao
  • Article
    | Open Access

    Besides its role in splicing, U1 snRNP can suppress pre-mRNA cleavage and polyadenylation. The authors show that the nuclear cap-binding complex component Srrt/Ars2 maintains embryonic stem cell identity by promoting U1 recruitment to first introns and preventing premature termination of multiple transcripts.

    • Yaroslav A. Kainov
    •  & Eugene V. Makeyev
  • Article
    | Open Access

    Sintering supported metal nanoparticles is the common route to the deactivation of industrial heterogeneous catalysts. Here, the authors report a carbon atomization process that allows one not only to redisperse metal nanoparticles, but also to recover deactivated catalysts.

    • Huang Zhou
    • , Yafei Zhao
    • , Jie Xu
    • , Haoran Sun
    • , Zhijun Li
    • , Wei Liu
    • , Tongwei Yuan
    • , Wei Liu
    • , Xiaoqian Wang
    • , Weng-Chon Cheong
    • , Zhiyuan Wang
    • , Xin Wang
    • , Chao Zhao
    • , Yancai Yao
    • , Wenyu Wang
    • , Fangyao Zhou
    • , Min Chen
    • , Benjin Jin
    • , Rongbo Sun
    • , Jing Liu
    • , Xun Hong
    • , Tao Yao
    • , Shiqiang Wei
    • , Jun Luo
    •  & Yuen Wu
  • Article
    | Open Access

    The unfolded protein response allows tumour cells to adapt to ER stress, and aberrant activation of Nrf2 confers cancer progression. Here, the authors show that TRIM25 is induced during ER stress and promotes tumour cell survival by targeting Keap1 for degradation, leading to Nrf2 activation.

    • Yanfeng Liu
    • , Shishi Tao
    • , Lijuan Liao
    • , Yang Li
    • , Hongchang Li
    • , Zhihuan Li
    • , Lilong Lin
    • , Xiaochun Wan
    • , Xiaolu Yang
    •  & Liang Chen
  • Article
    | Open Access

    Quantum calorimeters can provide time-resolved measurement of single photons by converting them to detectable temperature changes. Here the authors demonstrate a calorimeter that reaches the lower bound of temperature resolution, determined by the coupling to its heat bath and associated fluctuations.

    • Bayan Karimi
    • , Fredrik Brange
    • , Peter Samuelsson
    •  & Jukka P. Pekola
  • Article
    | Open Access

    Mechanisms behind molecular transport from cerebrospinal fluid to dural lymphatic vessels remain unknown. This study demonstrates that trans-arachnoid molecular passage does occur and suggests that parasagittal dura may serve as a bridging link between human brain and dural lymphatic vessels.

    • Geir Ringstad
    •  & Per Kristian Eide
  • Article
    | Open Access

    Precisely strained graphene layers can enable observation of periodic pseudo-magnetic fields with high symmetry. Here, the authors report experimental tuning of large area periodic pseudo-magnetic fields within twisted bilayer graphene and massive Dirac electrons having circularly localized pseudo-Landau levels.

    • Haohao Shi
    • , Zhen Zhan
    • , Zhikai Qi
    • , Kaixiang Huang
    • , Edo van Veen
    • , Jose Ángel Silva-Guillén
    • , Runxiao Zhang
    • , Pengju Li
    • , Kun Xie
    • , Hengxing Ji
    • , Mikhail I. Katsnelson
    • , Shengjun Yuan
    • , Shengyong Qin
    •  & Zhenyu Zhang
  • Article
    | Open Access

    Poliovirus has a higher mutation rate than HIV, yet has been almost eradicated by vaccination while an effective vaccine against HIV does not exist. Here, the authors develop a fitness model for poliovirus viral protein 1 to show that it is subject to stringent evolutionary constraints that limit its ability to avoid vaccine-induced immune responses.

    • Ahmed A. Quadeer
    • , John P. Barton
    • , Arup K. Chakraborty
    •  & Matthew R. McKay
  • Article
    | Open Access

    Mikania micrantha is an extremely fast-growing invasive plant species that can cause serious damage to natural ecosystems. Here, the authors assemble its chromosome-scale reference genome and explore possible mechanisms that contribute to its rapid growth.

    • Bo Liu
    • , Jian Yan
    • , Weihua Li
    • , Lijuan Yin
    • , Ping Li
    • , Hanxia Yu
    • , Longsheng Xing
    • , Minling Cai
    • , Hengchao Wang
    • , Mengxin Zhao
    • , Jin Zheng
    • , Feng Sun
    • , Zhenzhen Wang
    • , Zhaoyang Jiang
    • , Qiaojing Ou
    • , Shubin Li
    • , Lu Qu
    • , Qilei Zhang
    • , Yaping Zheng
    • , Xi Qiao
    • , Yu Xi
    • , Yan Zhang
    • , Fan Jiang
    • , Cong Huang
    • , Conghui Liu
    • , Yuwei Ren
    • , Sen Wang
    • , Hangwei Liu
    • , Jianyang Guo
    • , Haihong Wang
    • , Hui Dong
    • , Changlian Peng
    • , Wanqiang Qian
    • , Wei Fan
    •  & Fanghao Wan
  • Article
    | Open Access

    Despite growing aquaculture production and environmental concerns on phosphorus (P) enrichment, the P budgets of fisheries have been largely overlooked. Here, Huang et al. calculate global fishery P budgets and estimate P use efficiency for a wide range of aquaculture systems.

    • Yuanyuan Huang
    • , Phillipe Ciais
    • , Daniel S. Goll
    • , Jordi Sardans
    • , Josep Peñuelas
    • , Fabio Cresto-Aleina
    •  & Haicheng Zhang
  • Article
    | Open Access

    MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.

    • Yota Yasumizu
    • , Hasan Rajabi
    • , Caining Jin
    • , Tsuyoshi Hata
    • , Sean Pitroda
    • , Mark D. Long
    • , Masayuki Hagiwara
    • , Wei Li
    • , Qiang Hu
    • , Song Liu
    • , Nami Yamashita
    • , Atsushi Fushimi
    • , Ling Kui
    • , Mehmet Samur
    • , Masaaki Yamamoto
    • , Yan Zhang
    • , Ning Zhang
    • , Deli Hong
    • , Takahiro Maeda
    • , Takeo Kosaka
    • , Kwok K. Wong
    • , Mototsugu Oya
    •  & Donald Kufe
  • Article
    | Open Access

    The important tuberculosis drug pyrazinamide (PZA) is converted to its active form pyrazinoic acid (POA) in Mycobacterium tuberculosis (Mtb). Here the authors identify the pantothenate biosynthesis pathway enzyme aspartate decarboxylase (PanD) as the target of PZA and determine the POA bound Mtb PanD crystal structure.

    • Qingan Sun
    • , Xiaojun Li
    • , Lisa M. Perez
    • , Wanliang Shi
    • , Ying Zhang
    •  & James C. Sacchettini
  • Article
    | Open Access

    Despite recent progress in directed assembly of protein molecules into well-defined nanostructures, bridging materials fabrication from nano- to macroscale remains a challenge. Here, using silk fibroin as an example, the authors demonstrate templated crystallization to drive hierarchical materials growth from disordered molecules all the way up to centimeter scale.

    • Hui Sun
    •  & Benedetto Marelli
  • Article
    | Open Access

    In order to satisfy a wide range of modern microwave applications, improved methods are needed to produce low-noise microwave signals. Here the authors demonstrate ultra-low noise microwave synthesis via optical frequency division using a transfer oscillator method applied to a microresonator-based comb on the path to future self-referenced integrated sources.

    • Erwan Lucas
    • , Pierre Brochard
    • , Romain Bouchand
    • , Stéphane Schilt
    • , Thomas Südmeyer
    •  & Tobias J. Kippenberg
  • Article
    | Open Access

    Despite their importance as mechanistic models for Haber Bosch ammonia synthesis from N2 and H2, high oxidation state terminal metal-nitrides are notoriously unreactive towards H2. Here, the authors report hydrogenolysis of a uranium(V)-nitride, which can occur directly or by Frustrated Lewis Pair chemistry with a borane ancillary.

    • Lucile Chatelain
    • , Elisa Louyriac
    • , Iskander Douair
    • , Erli Lu
    • , Floriana Tuna
    • , Ashley J. Wooles
    • , Benedict M. Gardner
    • , Laurent Maron
    •  & Stephen T. Liddle
  • Article
    | Open Access

    Auxin promotes lateral root emergence from pericycle cells in the root vasculature. Here the authors show that induction of the plasmodesmal regulator PDLP5 during lateral root emergence restricts the spatial scope of auxin signaling to the cells overlying the primordia.

    • Ross Sager
    • , Xu Wang
    • , Kristine Hill
    • , Byung-Chun Yoo
    • , Jeffery Caplan
    • , Alex Nedo
    • , Thu Tran
    • , Malcolm J. Bennett
    •  & Jung-Youn Lee
  • Article
    | Open Access

    Acoustic communication is widespread, but not universal, across terrestrial vertebrates. Here, the authors show that acoustic communication evolved anciently, but independently, in most tetrapod groups and that these origins were associated with nocturnal activity.

    • Zhuo Chen
    •  & John J. Wiens
  • Article
    | Open Access

    The impact of bacteriophages in the human gut microbiome remains poorly understood. Here, the authors characterize coliphages isolated from a large cohort of 1-year-old infants and show that temperate coliphages dominate, while virulent ones have greater infectivity and broader host range.

    • Aurélie Mathieu
    • , Moïra Dion
    • , Ling Deng
    • , Denise Tremblay
    • , Elisabeth Moncaut
    • , Shiraz A. Shah
    • , Jakob Stokholm
    • , Karen A. Krogfelt
    • , Susanne Schjørring
    • , Hans Bisgaard
    • , Dennis S. Nielsen
    • , Sylvain Moineau
    •  & Marie-Agnès Petit
  • Article
    | Open Access

    The Hsp70 system prevents protein aggregation and increases folding yields, but it is unknown whether it also enhances the rate of folding. Here the authors combine refolding assays, FRET and hydrogen/deuterium exchange-mass spectrometry measurements to study the folding of firefly luciferase and find that the bacterial Hsp70 actively promotes the folding of this multi-domain protein.

    • Rahmi Imamoglu
    • , David Balchin
    • , Manajit Hayer-Hartl
    •  & F. Ulrich Hartl
  • Article
    | Open Access

    In spatial adiabatic passage, matter wave is transported between states without populating the intermediate quantum state. Here the authors demonstrate the spatial adiabatic passage using ultracold 171Yb atoms in Lieb-type optical lattices.

    • Shintaro Taie
    • , Tomohiro Ichinose
    • , Hideki Ozawa
    •  & Yoshiro Takahashi
  • Article
    | Open Access

    Decrease of friction during seismic slip is linked to temperature increase and weak phases production inside the fault core. Here the authors propose a mathematical framework which explains the frictional behaviour of all materials reported in literature and precisely captures material weakening during fault slip.

    • Hadrien Rattez
    •  & Manolis Veveakis
  • Article
    | Open Access

    Plasmonic enhancements of light–matter interactions are generally maximal at short emitter–surface separations. Here, the authors investigate the impact of nonlocality, spill-out, and surface-assisted Landau damping at nanoscale separations using a mesoscopic electrodynamic framework.

    • P. A. D. Gonçalves
    • , Thomas Christensen
    • , Nicholas Rivera
    • , Antti-Pekka Jauho
    • , N. Asger Mortensen
    •  & Marin Soljačić